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Items: 1 to 20 of 47

1.

Longevity regulating pathway - multiple species

Aging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, recent work has shown that dietary restriction (DR) and genetic down-regulation of nutrient-sensing...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
2.

Longevity regulating pathway - multiple species

Aging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, recent work has shown that dietary restriction (DR) and genetic down-regulation of nutrient-sensing...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
3.

Longevity regulating pathway

Regulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan. Four pathways have been implicated in mediating the...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
4.

Phospholipase D signaling pathway

Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
5.

Phospholipase D signaling pathway

Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival....

Type
:
pathway
Taxonomic scope
:
conserved biosystem
6.

Insulin resistance

Insulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular diseases. In this diagram multiple mechanisms...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
7.

Regulation of lipolysis in adipocytes

Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. Lipolysis is under tight hormonal control. During fasting, catecholamines, by binding...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
8.

AMPK signaling pathway

AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
9.

AMPK signaling pathway

AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
10.

cGMP-PKG signaling pathway

Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms of cGMP-dependent...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
11.

cGMP-PKG signaling pathway

Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms of cGMP-dependent...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
12.

FoxO signaling pathway

The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
13.

Prostate cancer

Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
14.

Aldosterone-regulated sodium reabsorption

Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-term blood pressure. Aldosterone plays a major role in sodium and potassium metabolism...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
15.

Maturity onset diabetes of the young

About 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MODY). We now know that MODY is caused by heterozygous mutations in at least five genes...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
16.

Non-alcoholic fatty liver disease (NAFLD)

Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepatitis (NASH). NASH may further lead to cirrhosis and hepatocellular carcinoma (HCC)....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
17.

Type I diabetes mellitus

Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
18.

Type II diabetes mellitus

Insulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
19.

Prolactin signaling pathway

Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and metabolism, brain and behavior, and immunomodulation. PRL mediates its action through...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis
20.

Progesterone-mediated oocyte maturation

Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Macaca fascicularis

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