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Links from Nucleotide

Items: 1 to 20 of 997

1.

negative regulation of lipid localization

Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. Synonyms: down regulation of lipid localisation; down regulation of lipid localization; down-regulation of lipid localisation; down-regulation of lipid localization; downregulation of...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1495432
GO
: GO:1905953
2.

regulation of lipid localization

Any process that modulates the frequency, rate or extent of lipid localization. Synonym: regulation of lipid localisation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1495431
GO
: GO:1905952
3.

Fluid shear stress and atherosclerosis

Shear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress of atherosclerosis. Sustained laminar flow with high shear stress upregulates expressions...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

IL-17 signaling pathway

The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defined T helper 17 (TH17) cell subset, has important roles in protecting the host against...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

Fluid shear stress and atherosclerosis

Shear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress of atherosclerosis. Sustained laminar flow with high shear stress upregulates expressions...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
6.

IL-17 signaling pathway

The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defined T helper 17 (TH17) cell subset, has important roles in protecting the host against...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1473615
KEGG
: ko04657
7.

Interleukin-10 signaling

Interleukin-10 (IL10) was originally described as a factor named cytokine synthesis inhibitory factor that inhibited T-helper (Th) 1 activation and Th1 cytokine production (Fiorentino et al. 1989). It was found to be expressed by a variety of cell types including macrophages, dendritic...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

Interleukin-4 and 13 signaling

Interleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand in response to Interleukin-2 (IL2), they can differentiate as Type 1 (Th1) or Type...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
9.

Photodynamic therapy-induced AP-1 survival signaling.

Photodynamic therapy may induce an acute stress response mediated by mitogen-activated protein kinase kinase kinase 5 (MAP3K5), its downstream MAPKs that target c-Jun N-terminal kinase (JNK, MAPK8) and p38MAPK, and the transcription factors of the activator protein 1 (AP-1) famil...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
10.

Cardiac Hypertrophic Response

Integrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
11.

Aryl Hydrocarbon Receptor Pathway

The aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic metabolism (including for example cytochrome P540 enzymes).

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
12.

Overview of nanoparticle effects

This pathway is giving a summary of currently known nanoparticle effects on cells and organisms. Although there is currently no nanoparticle specific effect known, there is a cascade of effects triggered if cells or organisms are exposed to nanoparticles: The most abundantly observed...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
13.

T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection

This pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway"(see bibliography)....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
14.

EV release from cardiac cells and their functional effects

Summary of reported EV release from cardiac cells in culture and their functional effects. EV release has been reported in numerous cell lines and primary cultures, both at baseline and in response to stimuli. Transfer of EVs between cell types has been demonstrated as well as delivery...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
15.

TLR4 Signaling and Tolerance

This pathway is based on the figure 2 of "Toll-like Receptors: Novel Pharmacological Targets for the Treatment of Neurological Diseases" and figure 2 of "Toll-like receptor and its roles in myocardial ischemic/reperfusion injury" (see bibliography). The Toll-like receptors are used...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
16.

Photodynamic therapy-induced NF-kB survival signaling

Photodynamic therapy may induce a pro-inflammatory and angiogenic response mediated by NF-?B.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
17.

RIG-I-like Receptor Signaling

Viral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initiate signaling pathways, triggering the innate antiviral response via production of...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
18.

Development and heterogeneity of the ILC family

Development and heterogeneity of the ILC family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription factors and cytokines are involved in the development of the three groups of mature...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
19.

Lung fibrosis

Lung fibrosis pathway linked to events (molecular initiating event, key events and associative events) in a putative Adverse Outcome Pathway for lung fibrosis.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
20.

Aryl Hydrocarbon Receptor

The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem

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