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Items: 6

1.

beta-catenin-TCF7L2 complex

A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. Synonym: beta-catenin-TCF4 complex;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
515301
GO
: GO:0070369
2.

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. Synonyms: GO:0010552; GO:0045817; activation of global transcription from RNA polymerase II promoter; activation of transcription from RNA polymerase II promoter;...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
508249
GO
: GO:0045944
3.

transcription coactivator activity

Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
489258
GO
: GO:0003713
4.

S45 mutants of beta-catenin aren't phosphorylated

S45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish the CK1alpha phosphorylation site of beta-catenin which acts as a critical priming site...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex

Mutations in exon 3 of the beta-catenin gene have been identified in a number of human cancers (Morin et al, 1997; Rubinfeld et al, 1997; reviewed in Polakis, 2000; Polakis, 2007). These mutations generally affect serine and threonine residues (S33, S37, T41, S45) that are the sites...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

truncated APC mutants destabilize the destruction complex

APC is a large and central component of the destruction complex, which limits signaling in the absence of WNT ligand by promoting the ubiquitin-mediated degradation of beta-catenin. APC interacts with numerous components of the destruction complex, including AXINs (AXIN1 and AXIN2),...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens

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