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ubiquitin-dependent ERAD pathway

The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. Synonyms: ER-associated ubiquitin-dependent protein breakdown; ER-associated ubiquitin-dependent protein catabolic process; ER-associated ubiquitin-dependent protein catabolism; ER-associated ubiquitin-dependent protein degradation; ERAD; endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process; endoplasmic reticulum-associated ubiqutin-dependent protein catabolism; ubiquitin-dependent proteasomal protein catabolism of ER proteins;

from GO source record: GO:0030433
Type: pathway
Taxonomic scope
conserved biosystem

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