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urea degradation I

Many organisms possess enzymes for the transformation of : UREA into : AMMONIA and :CARBON-DIOXIDE. This conversion can occur in two distinct routes, catalyzed by the enzymes : CPLX-6897 and :ENZRXN3O-319, respectively. Urease catalyzes the ATP independent cleavage of the amide bonds of urea, forming : AMMONIA and :CARBON-DIOXIDE in a single step. Ureases have been described in plants, fungi, and bacteria (see : PWY-5704). :ENZRXN3O-319 (also known as urea amidolyase) enzymes have been known for quite a while in yeast and algae , and more recently were found in bacteria . All of these organisms lack a urease. Urea amidolyase catalyzes the ATP-dependent hydrolysis of : UREA to : AMMONIA and carbonic acid with : CPD-578 (allophanate) as an intermediate. The overall reaction consists of two independent enzymatic reactions - the carboxylation of urea, followed by hydrolysis of : CPD-578 to : AMMONIA and :CARBON-DIOXIDE. While in yeast both activities are performed by a single polypeptide , in algae they are catalyzed by two separate enzymes, urea carboxylase and allophanate hydrolase .

from BIOCYC source record: CHLAMY_PWY-5703
Type: pathway
Taxonomic scope
organism-specific biosystem
Chlamydomonas reinhardtii

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