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bacillithiol biosynthesis

General Background Thiols are compounds that play a major role in the detoxification of stress-inducing factors. Pathogenic bacteria live in a particularly hostile environment, in which the host deliberately generates toxins, including reactive oxygen species, to destroy the invading organism. Thus thiols are particularly important for the survival of these organisms. While : GLUTATHIONE is the major low-molecular-weight thiol in eukaryotic organisms, Gram-negative bacteria and some Gram-positive bacteria, it is not universal . In some organisms other thiols have taken its role, including : CoM, : TRYPANOTHIONE, ergothioneine, : CPD1G-2, and the ovothiols. The small thiol : CPD8J2-3 has been discovered in a variety of Gram-positive bacteria, including Deinococcus radiodurans, Bacillus anthracis, Staphylococcus aureus, and Bacillus subtilis . Genes similar to those of the B. subtilis biosynthetic pathway were also discovered in the δ-proteobacterium Myxococcus xanthus and the halophilic alkalithermophile Natranaerobius thermophilus . About This Pathway A pathway for the biosynthesis of bacillithiol was proposed based on parallels to the : PWY1G-0 pathway, and candidate enzymes were identified by bioinformatic analysis. The function of the first enzyme of the pathway, : BSU22460-MONOMER, was confirmed by assays of the purified protein and its mutant phenotype. Two acetylases with partially redundant function catalyze the second reaction, deacetylation of : CPD8J2-1. The last enzyme of the pathway, a cysteine-adding enzyme, was identified by its mutant phenotype . The redox buffer provided by bacillithiol protects the cells against NaOCl stress . Bacillithiol also serves as a buffer of the labile zinc pool in the cell .

from BIOCYC source record: BSUB_PWY8J2-1
Type: pathway
Taxonomic scope
organism-specific biosystem
Bacillus subtilis

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