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Items: 8

1.

pre-mRNA binding

Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. Synonym: protein-coding...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
750927
GO
: GO:0036002
2.

U2-type catalytic step 2 spliceosome

A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome,...

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
515933
GO
: GO:0071007
3.

U2-type catalytic step 1 spliceosome

A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome,...

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
515932
GO
: GO:0071006
4.

mRNA cis splicing, via spliceosome

The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. Synonyms: nuclear...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
507651
GO
: GO:0045292
5.

U6 snRNA binding

Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
496887
GO
: GO:0017070
6.

spliceosomal snRNP assembly

The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. Synonym: spliceosomal snRNP biogenesis;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
486884
GO
: GO:0000387
7.

second spliceosomal transesterification activity

Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
486871
GO
: GO:0000386
8.

first spliceosomal transesterification activity

Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
486870
GO
: GO:0000384

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