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Items: 8

1.

mitotic G1 DNA damage checkpoint

A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage. Synonym: mitotic cell cycle G1/S transition DNA damage checkpoint;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
500822
GO
: GO:0031571
2.

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
500433
GO
: GO:0031146
3.

cyclin binding

Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
499733
GO
: GO:0030332
4.

enzyme binding

Interacting selectively and non-covalently with any enzyme.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
496935
GO
: GO:0019899
5.

SCF ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The...

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
493942
GO
: GO:0019005
6.

cellular response to DNA damage stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. Synonyms: DNA damage response;...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
491813
GO
: GO:0006974
7.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). Synonyms: GO:0045308; alpha-2 macroglobulin receptor-associated protein activity; protein amino acid binding; protein degradation...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
486730
GO
: GO:0005515
8.

G1/S transition of mitotic cell cycle

The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
486622
GO
: GO:0000082

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