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Items: 4

1.

cholesterol monooxygenase (side-chain-cleaving) activity

Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. Synonyms: C27-side chain cleavage enzyme; Cyp11a1; cholesterol 20-22-desmolase activity; cholesterol C(20-22) desmolase activity; cholesterol...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
492686
GO
: GO:0008386
2.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
492544
GO
: GO:0008203
3.

C21-steroid hormone biosynthetic process

The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. Synonyms: C21-steroid hormone anabolism; C21-steroid hormone biosynthesis; C21-steroid hormone formation; C21-steroid hormone...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
491587
GO
: GO:0006700
4.

Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)

Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) normally catalyses the side-chain cleavage of cholesterol to form pregnenolone. Defects in CYP11A1 can cause Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR; MIM:613743). This is a rare disorder that...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens

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