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piperine biosynthesis

Piperine is an alkaloid that gives the pungent flavor of black pepper (Piper nigrum) and related species. Piperine in diet can stimulate the digestive enzymes of pancreas and enhance the digestive capacity. It has also been documented to enhance the bioavailability of a number of therapeutic drugs. Although non-genotoxic, piperine has been found to have anti-mutagenic and anti-tumor influences (see a recent review |CITS: [17987447]|). Very little is known of its biosynthesis route. A substrate-specific piperoyltransferase activity detected in the shoots of black pepper showed that piperine can be synthesized from piperidine and piperoyl-CoA. The reaction forming an acid-amide linkage is analogous of |FRAME:PWY-5474|. No reports are available on the reactions leading to the two precursors of piperine, piperidine and piperoyl-CoA.

from BIOCYC source record: META_PWY-5752
Type: pathway
Taxonomic scope
conserved biosystem

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