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Items: 19

1.

U4/U6 x U5 tri-snRNP complex

A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. Synonym: U4/U6.U5 snRNP complex;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
508797
GO
: GO:0046540
2.

alignment of 3' and 5' splice sites of mRNA

Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur. Synonym: alignment of 3' and 5' splice sites of nuclear mRNA;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
503605
GO
: GO:0034403
3.

pre-mRNA 5'-splice site binding

Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence. Synonym: pre-mRNA 5' splice site binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
499935
GO
: GO:0030627
4.

U2 snRNA binding

Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA).

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
499928
GO
: GO:0030620
5.

U1 snRNA binding

Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA).

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
499927
GO
: GO:0030619
6.

U6 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U6. Synonym: snRNP U6;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
490742
GO
: GO:0005688
7.

U2 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U2. Synonyms: 17S U2 snRNP; snRNP U2;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
490740
GO
: GO:0005686
8.

U1 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U1. Synonym: snRNP U1;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
490739
GO
: GO:0005685
9.

U5 snRNP

A ribonucleoprotein complex that contains small nuclear RNA U5. Synonym: snRNP U5;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
490736
GO
: GO:0005682
10.

spliceosomal complex

Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs...

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
490735
GO
: GO:0005681
11.

mRNA binding

Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
489272
GO
: GO:0003729
12.

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof. Synonyms: GO:0044822; poly(A) RNA binding; poly(A)-RNA binding; poly-A RNA binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
489267
GO
: GO:0003723
13.

mRNA splicing, via spliceosome

The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. Synonyms: GO:0006374; GO:0006375; mRNA splicing; nuclear mRNA...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
486891
GO
: GO:0000398
14.

mRNA 5'-splice site recognition

Recognition of the intron 5'-splice site by components of the assembling spliceosome. Synonyms: GO:0000368; GO:0000369; U12-type nuclear mRNA 5' splice site recognition; U12-type nuclear mRNA 5'-splice site recognition; U2-type nuclear mRNA 5' splice site recognition; U2-type nuclear...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
486890
GO
: GO:0000395
15.

spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)

Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11). Synonyms: 3'-splice site cleavage, exon ligation; GO:0000396; GO:0000397;...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
486885
GO
: GO:0000388
16.

RNA splicing, via transesterification reactions

Splicing of RNA via a series of two transesterification reactions. Synonyms: GO:0000385; GO:0031202; RNA splicing factor activity, transesterification mechanism; pre-mRNA splicing factor activity; spliceosomal catalysis;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
486877
GO
: GO:0000375
17.

second spliceosomal transesterification activity

Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
486871
GO
: GO:0000386
18.

generation of catalytic spliceosome for second transesterification step

Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. Synonyms: GO:0000358; GO:0000359; catalytic spliceosome assembly for second transesterification step; formation...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
486866
GO
: GO:0000350
19.

commitment complex

A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript. Synonyms: mammalian spliceosomal E complex; mammalian spliceosomal complex E; yeast spliceosomal complex CC;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
486761
GO
: GO:0000243

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