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Items: 19

1.

positive regulation of NF-kappaB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. Synonyms: NF-kappaB activation; activation of NF-kappaB; activation of NF-kappaB transcription factor;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512006
GO
: GO:0051092
2.

interleukin-12 complex

A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space. Synonyms: IL-12 complex; IL12A; IL12B; p35; p40;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
506545
GO
: GO:0043514
3.

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer. Synonym: dimerization activity;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
505906
GO
: GO:0042803
4.

interleukin-12 alpha subunit binding

Interacting selectively and non-covalently with the alpha subunit of interleukin-12. Synonyms: CLMFp35 binding; IL-12A binding; IL-12p35 binding; NKSFp35 binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
505326
GO
: GO:0042164
5.

interleukin-12 beta subunit binding

Interacting selectively and non-covalently with the beta subunit of interleukin-12. Synonyms: CLMFp40 binding; IL-12B binding; IL-12p40 binding; NKSFp40 binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
505325
GO
: GO:0042163
6.

negative regulation of toll-like receptor 2 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway. Synonyms: negative regulation of TLR2 signaling pathway; negative regulation of toll-like receptor 2 signalling pathway;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
503342
GO
: GO:0034136
7.

positive regulation of tumor necrosis factor production

Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production. Synonyms: activation of tumor necrosis factor production; positive regulation of TNF production; positive regulation of TNF-alpha production; positive regulation of tumor necrosis...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501986
GO
: GO:0032760
8.

positive regulation of interleukin-12 production

Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. Synonyms: activation of interleukin-12 production; positive regulation of IL-12 production; stimulation of interleukin-12 production; up regulation of interleukin-12 production; up-regulation...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501961
GO
: GO:0032735
9.

negative regulation of interleukin-18 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production. Synonyms: down regulation of interleukin-18 production; down-regulation of interleukin-18 production; downregulation of interleukin-18 production; inhibition of interleukin-18...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501927
GO
: GO:0032701
10.

negative regulation of interleukin-12 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. Synonyms: down regulation of interleukin-12 production; down-regulation of interleukin-12 production; downregulation of interleukin-12 production; inhibition of interleukin-12...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501921
GO
: GO:0032695
11.

negative regulation of interferon-gamma production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. Synonyms: down regulation of interferon-gamma production; down-regulation of interferon-gamma production; downregulation...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501915
GO
: GO:0032689
12.

response to muramyl dipeptide

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501727
GO
: GO:0032495
13.

response to peptidoglycan

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501726
GO
: GO:0032494
14.

negative regulation of NF-kappaB transcription factor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. Synonyms: NF-kappaB inhibitor; inhibition of NF-kappaB transcription factor;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
501325
GO
: GO:0032088
15.

external side of plasma membrane

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. Synonyms: external leaflet of plasma membrane; juxtamembrane; outer surface of cytoplasmic membrane;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
493991
GO
: GO:0009897
16.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized...

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
490701
GO
: GO:0005634
17.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. Synonym: intercellular space;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
490687
GO
: GO:0005615
18.

cytokine production

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Synonyms: interferon production; interleukin production;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
487712
GO
: GO:0001816
19.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). Synonyms: GO:0045308; alpha-2 macroglobulin receptor-associated protein activity; protein amino acid binding; protein degradation...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
486730
GO
: GO:0005515

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