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Items: 5

1.

histone acetyltransferase binding

Interacting selectively and non-covalently with the enzyme histone acetyltransferase. Synonym: histone acetylase binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
504223
GO
: GO:0035035
2.

transcription factor binding

Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. Synonym: TF binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
492489
GO
: GO:0008134
3.

GLI proteins bind promoters of Hh responsive genes to promote transcription

GLI proteins are bifunctional DNA-binding proteins that recognize consensus GLI sites 5'-GACCACCC-3' in the promoters of target genes (Kinzler and Vogelstein, 1990). Pathway induction upon ligand-binding diverts the GLI proteins from the processing/degradation pathway that generates...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Degradation of GLI1 by the proteasome

GLI1 is the most divergent of the 3 mammalian GLI transcription factors and lacks a transcriptional repressor domain. Although GLI1 is dispensible for development, the gene is an early transcriptional target of Hh signaling and the protein contributes a minor activation function...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

Hedgehog signaling events mediated by Gli proteins

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens

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