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Links from Protein

Items: 1 to 20 of 96

1.

AURKA Activation by TPX2

TPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. 2003, Xu et al. 2011, Giubettini et al. 2011, Dodson and Bayliss 2012).

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
2.

Loss of Nlp from mitotic centrosomes

During interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated at the onset of mitosis and phosphorylates Nlp triggering its displacement from...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
3.

Regulation of PLK1 Activity at G2/M Transition

The kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalytically activated through AJUBA facilitated autophosphorylation on threonine residue T288...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Anchoring of the basal body to the plasma membrane

Cilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core surrounded by a ring of nine microtubule triplets; the mother centriole additionally...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

Loss of proteins required for interphase microtubule organization from the centrosome

In addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization and centrosome cohesion (Casenghi et al., 2003; Mayor et al., 2002).

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

Recruitment of mitotic centrosome proteins and complexes

The mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centrosomes recruiting additional gamma TuRC complexes and acquiring mitosis-associated...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

Cilium Assembly

Cilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguished by the structure of their microtubule-based axonemes. The axoneme consists of nine...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

G2/M Transition

Cyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of T14 and Y15. Cyclin A, B - Cdc2 complexes phosphorylate several proteins involved...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
9.

Centrosome maturation

The centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an early event in this process and involves a major reorganization of centrosomal material...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
10.

Organelle biogenesis and maintenance

This module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reticulum, Golgi apparatus, vacuoles, nucleus, (auto)phagosome, centriole, lysosome, melanosome,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
11.

mitotic cell cycle process

A process that is part of the mitotic cell cycle.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
987848
GO
: GO:1903047
12.

cell cycle G2/M phase transition

The cell cycle process by which a cell in G2 phase commits to M phase.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
948853
GO
: GO:0044839
13.

mitotic cell cycle phase transition

The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
777516
GO
: GO:0044772
14.

cell cycle phase transition

The cell cycle process by which a cell commits to entering the next cell cycle phase. Synonym: cell cycle transition;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
777514
GO
: GO:0044770
15.

regulation of protein depolymerization

Any process that modulates the frequency, rate or extent of protein depolymerization. Synonyms: regulation of protein polymer breakdown; regulation of protein polymer catabolic process; regulation of protein polymer catabolism; regulation of protein polymer degradation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
754830
GO
: GO:1901879
16.

organelle assembly

The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
515852
GO
: GO:0070925
17.

HAUS complex

A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex. Synonym:...

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
515582
GO
: GO:0070652
18.

biological regulation

Any process that modulates a measurable attribute of any biological process, quality or function. Synonym: regulation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
514938
GO
: GO:0065007
19.

cell division

The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512185
GO
: GO:0051301
20.

centrosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized....

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512182
GO
: GO:0051297

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