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Items: 1 to 20 of 154

1.

Herpes simplex infection

Herpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishment of latent infection in neuronal ganglia. HSV is the main cause of herpes infections...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
2.

Gap-filling DNA repair synthesis and ligation in TC-NER

In transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fill in the single stranded gap that remains after dual incision. DNA ligases LIG1 or...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
3.

Dual incision in TC-NER

In transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), the oligonucleotide that contains the lesion is excised from the open bubble structure via dual incision of the affected DNA strand. 5' incision by the ERCC1:ERCC4...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Formation of TC-NER Pre-Incision Complex

Formation of TC-NER pre-incision complex is initiated when the RNA polymerase II (RNA Pol II) complex stalls at a DNA damage site. The stalling is caused by misincorporation of a ribonucleotide opposite to a damaged base (Brueckner et al. 2007). Cockayne syndrome protein B (ERCC6,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

ATM Signaling Network in Development and Disease

This pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage through the appropriate cellular programs such as transcription, translation, etc etc....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
6.

Transcription-Coupled Nucleotide Excision Repair (TC-NER)

DNA damage in transcribed strands of active genes is repaired through a specialized nucleotide excision repair (NER) pathway known as transcription-coupled nucleotide excision repair (TC-NER). TC-NER impairment is the underlying cause of a severe hereditary disorder Cockayne syndrome,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

Herpes simplex infection

Herpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishment of latent infection in neuronal ganglia. HSV is the main cause of herpes infections...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
377865
KEGG
: ko05168
8.

p38 MAPK Signaling Pathway

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
9.

Nucleotide Excision Repair

Nucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recovery of DNA synthesis and cell survival. Deficient NER processes have been identified...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
10.

DNA Repair

DNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, environmental chemicals and radiation that damage their DNA, thus corrupting genetic information....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
11.

regulation of nucleic acid-templated transcription

Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1129333
GO
: GO:1903506
12.

macromolecular complex binding

Interacting selectively and non-covalently with any macromolecular complex.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
1129214
GO
: GO:0044877
13.

regulation of RNA biosynthetic process

Any process that modulates the frequency, rate or extent of RNA biosynthetic process. Synonyms: regulation of RNA anabolism; regulation of RNA biosynthesis; regulation of RNA formation; regulation of RNA synthesis;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
755247
GO
: GO:2001141
14.

positive regulation of NAD+ ADP-ribosyltransferase activity

Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity. Synonyms: activation of ADP-ribosyltransferase (polymerizing) activity; activation of NAD ADP-ribosyltransferase activity; activation of NAD+ ADP-ribosyltransferase activity;...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
754618
GO
: GO:1901666
15.

organic cyclic compound binding

Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
752660
GO
: GO:0097159
16.

single-organism developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
751909
GO
: GO:0044767
17.

biological regulation

Any process that modulates a measurable attribute of any biological process, quality or function. Synonym: regulation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
514938
GO
: GO:0065007
18.

cellular response to stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512589
GO
: GO:0051716
19.

positive regulation of transferase activity

Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. Synonyms: activation...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512231
GO
: GO:0051347
20.

regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. Synonym: regulation of RNA metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512143
GO
: GO:0051252

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