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Links from Protein

Items: 1 to 20 of 277

1.

HTLV-I infection

Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
2.

ATF4 activates genes

ATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
3.

Photodynamic therapy-induced unfolded protein response

Photodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, and ATF4.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
4.

PERK regulates gene expression

PERK (EIF2AK3) is a single-pass transmembrane protein located in the endoplasmic reticulum (ER) membrane such that the N-terminus of PERK is luminal and the C-terminus is cytosolic. PERK is maintained in an inactive form by interaction of its luminal domain with BiP, an ER chaperone....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

HTLV-I infection

Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)....

Type
:
pathway
Taxonomic scope
:
conserved biosystem
6.

Myometrial Relaxation and Contraction Pathways

This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
7.

ATF-2 transcription factor network

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

Regulation of nuclear SMAD2/3 signaling

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
9.

Direct p53 effectors

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
10.

Metabolism of proteins

Protein metabolism comprises the pathways of translation, post-translational modification and protein folding.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
11.

sequence-specific double-stranded DNA binding

Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. Synonym: sequence-specific dsDNA binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
1310813
GO
: GO:1990837
12.

Unfolded Protein Response (UPR)

The Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER during times of unusually high secretion activity. Analysis of mutants with altered...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
13.

CHOP-ATF3 complex

A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits. Synonyms: ATF3-CHOP complex; CHOP-ATF3 heterodimer; CHOP-ATF3 heterodimeric complex; GADD153-ATF3 complex;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
1184591
GO
: GO:1990622
14.

positive regulation of TRAIL-activated apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway. Synonyms: activation of TRAIL-activated apoptotic signaling pathway; activation of TRAIL-activated extrinsic apoptotic signaling pathway; activation of TRAIL-induced...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1184510
GO
: GO:1903984
15.

PERK-mediated unfolded protein response

A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1184349
GO
: GO:0036499
16.

negative regulation of nucleic acid-templated transcription

Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription. Synonyms: down regulation of nucleic acid-templated transcription; down-regulation of nucleic acid-templated transcription; downregulation of nucleic acid-templated transcription;...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1129334
GO
: GO:1903507
17.

regulation of nucleic acid-templated transcription

Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1129333
GO
: GO:1903506
18.

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. Synonyms: ER stress-induced upregulation of transcription; activation of transcription from RNA polymerase II promoter...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1025448
GO
: GO:1990440
19.

negative regulation of RNA biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. Synonyms: down regulation of RNA anabolism; down regulation of RNA biosynthesis; down regulation of RNA biosynthetic process; down regulation of RNA formation; down regulation of...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
948122
GO
: GO:1902679
20.

negative regulation of intracellular signal transduction

Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. Synonyms: GO:0010741; down regulation of intracellular signal transduction; down regulation of intracellular signal transduction pathway; down regulation of intracellular...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
921131
GO
: GO:1902532

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