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Items: 1 to 20 of 131

1.

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

In the synthesis-dependent strand-annealing (SDSA) model of D-loop resolution, D-loop strands extended by DNA repair synthesis dissociate from their sister chromatid complements and reanneal with their original complementary strands, resulting in non-crossover products (Mitchel et...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
2.

Resolution of D-loop Structures through Holliday Junction Intermediates

D-loops generated after strand invasion and DNA repair synthesis during homologous recombination repair (HRR) can be resolved through Holliday junction intermediates.A D-loop can be cleaved by the complex of MUS81 and EME1 (MUS81:EME1) or MUS81 and EME2 (MUS81:EME2) and resolved without...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
3.

Resolution of D-Loop Structures

Once repair synthesis has occurred, the D-loop structure may be resolved either through Holliday junction intermediates or through synthesis-dependent strand-annealing (SDSA) (Prado and Aguilera 2003, Ciccia and Elledge 2010).

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Homologous DNA Pairing and Strand Exchange

The presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from 3'-ssDNA overhangs created by extensive resection of DNA double strand break (DSB) ends. RPA is displaced by the joint action of RAD51 and BRCA2. BRCA2 nucleates RAD51 on 3'-ssDNA...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

HDR through Homologous Recombination (HRR)

Homology directed repair (HDR) through homologous recombination is known as homologous recombination repair (HRR). HRR occurs after extensive resection of DNA double strand break (DSB) ends, which creates long 3'-ssDNA overhangs. RAD51 coats 3'-ssDNA overhangs in a BRCA2-controlled...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)

Homology directed repair (HDR) of replication-independent DNA double strand breaks (DSBs) via homologous recombination repair (HRR) or single strand annealing (SSA) requires the activation of ATM followed by ATM-mediated phosphorylation of DNA repair proteins. ATM coordinates the...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

Homology Directed Repair

Homology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homologous sequence can then be used as a template for DNA repair synthesis that bridges...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

DNA Double-Strand Break Repair

Numerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-strand breaks (DSBs), one of the most dangerous type of DNA damage along with interstrand...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
9.

DNA Repair

DNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, environmental chemicals and radiation that damage their DNA, thus corrupting genetic information....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
10.

organic substance biosynthetic process

The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. Synonyms: organic molecular entity anabolism; organic molecular entity biosynthesis; organic molecular entity biosynthetic process; organic molecular entity...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
754533
GO
: GO:1901576
11.

heterocyclic compound binding

Interacting selectively and non-covalently with heterocyclic compound.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
754325
GO
: GO:1901363
12.

organic cyclic compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic cyclic compound. Synonyms: organic cyclic compound anabolism; organic cyclic compound biosynthesis; organic cyclic compound formation; organic cyclic compound synthesis;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
754324
GO
: GO:1901362
13.

organic cyclic compound metabolic process

The chemical reactions and pathways involving organic cyclic compound. Synonym: organic cyclic compound metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
754322
GO
: GO:1901360
14.

organic cyclic compound binding

Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
752660
GO
: GO:0097159
15.

single-organism developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
751909
GO
: GO:0044767
16.

single-organism cellular process

Any process that is carried out at the cellular level, occurring within a single organism.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
751905
GO
: GO:0044763
17.

single-organism metabolic process

A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
751852
GO
: GO:0044710
18.

single-multicellular organism process

A biological process occurring within a single, multicellular organism.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
751850
GO
: GO:0044707
19.

single-organism process

A biological process that involves only one organism. Synonym: single organism process;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
751843
GO
: GO:0044699
20.

post-anal tail morphogenesis

The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
750843
GO
: GO:0036342

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