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Items: 1 to 20 of 402

1.

Apelin signaling pathway

Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
1492886
KEGG
: hsa04371
2.

Angiopoietin Like Protein 8 Regulatory Pathway

The hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated signaling events of insulin signaling in the liver.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
3.

Bladder Cancer

The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma are bladder carcinomas, and urothelial carcinomas of the renal pelvis and ureter...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
4.

Cardiac Hypertrophic Response

Integrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
5.

Structural Pathway of Interleukin 1 (IL-1)

Pathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 IL-1 signaling pathway reconstructed by combining related pathways and information from the literature. This detailed map of IL-1 signaling presents the protein-protein interactions...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
6.

Hepatitis C and Hepatocellular Carcinoma

Pathway model based on hub miRNAs and their putative targets from network analysis. - From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/)...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
7.

T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection

This pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway"(see bibliography)....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
8.

Rac1/Pak1/p38/MMP-2 pathway

Rac1/p38 pathway from Ingenuity Pathway Analysis.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
9.

4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression

This pathway is modeled after Figure 7 in the article ''Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids'' (See Bibliography). Several anticancer agents up-regulate expression of p27, a cyclin-dpendent...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
10.

BDNF-TrkB Signaling

Brain-derived neurotrophic factor (BDNF) is an important neurotrophin for the regulation of synaptic activity. BDNF-TrkB signaling, TrkB being the receptor of BDNF, is involved in transcription, translation, and trafficking of proteins in the various stages of synaptic development...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
11.

Association Between Physico-Chemical Features and Toxicity Associated Pathways

This pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstrate close links between pathways associated with chemical hits and pathways associated...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
12.

Aryl Hydrocarbon Receptor

The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
13.

Common Pathways Underlying Drug Addiction

The pathway was modeled after Figure 2 in Li, et al. 2008 and is based on the common pathways identified in their study as well as protein interaction data. Specifically, glutamate and dopamine neuroactive ligand-receptor interactions trigger long-term potentiation, MAPK and GnRH...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
14.

Nanoparticle-mediated activation of receptor signaling

Nanoparticle-mediated activation of receptor signaling. Several NP formulations were shown to interact with cellular receptors such as the EGFR and integrins, inducing cellular phenotypes such as proliferation, apoptosis, differentiation, and migration. In lung epithelial cells, NPs...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
15.

MET activates PTPN11

PTPN11 (SHP2), recruited to activated MET receptor through GAB1, is phosphorylated in response to HGF treatment, although phosphorylation sites and direct MET involvement have not been examined (Schaeper et al. 2000, Duan et al. 2006). Phosphorylation of PTPN11 in response to HGF...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
16.

Signaling by MET

MET is a receptor tyrosine kinase (RTK) (Cooper et al. 1984, Park et al. 1984) activated by binding to its ligand, Hepatocyte growth factor/Scatter factor (HGF/SF) (Bottaro et al. 1991, Naldini et al. 1991). Similar to other related RTKs, such as EGFR, ligand binding induces MET dimerization...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
17.

Signaling by BRAF and RAF fusions

In addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et al, 2011; Palanisamy et al, 2010; Ciampi et al, 2005; Stransky et al, 2014; Hutchinson...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
18.

Paradoxical activation of RAF signaling by kinase inactive BRAF

While BRAF-specific inhibitors inhibit MAPK/ERK activation in the presence of the BRAF V600E mutant, paradoxical activation of ERK signaling has been observed after treatment of cells with inhibitor in the presence of WT BRAF (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010;...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
19.

Signaling by moderate kinase activity BRAF mutants

In addition to the highly prevalent and activating V600E BRAF mutations, numerous moderately activating and less common mutations have also been identified in human cancers (Forbes et al, 2015). Unlike the case for their highly activating counterparts, signaling through these mutant...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
20.

Signaling by high-kinase activity BRAF mutants

BRAF is mutated in about 8% of human cancers, with high prevalence in hairy cell leukemia, melanoma, papillary thyroid and ovarian carcinomas, colorectal cancer and a variety of other tumors (Davies et al, 2002; reviewed in Samatar and Poulikakos, 2014). Most BRAF mutations fall in...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens

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