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Items: 8

1.

Constitutive Androstane Receptor Pathway

The Constitutive Androstane Receptor (CAR) is a nuclear receptor and functions as a sensor for xenobiotics. It regulates transcription of genes encoding proteins in metabolism and excretion of xenobiotics

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
2.

Nuclear Receptor transcription pathway

A classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other small, diffusible signaling molecules. The non-liganded NRs recruit specific corepressor...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
3.

Generic Transcription Pathway

OVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or tissue-specific regulation of differential gene transcription is mediated (reviewed...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Nuclear Receptors

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
5.

Glucocorticoid receptor regulatory network

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

Drug Induction of Bile Acid Pathway

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
7.

Nuclear Receptors in Lipid Metabolism and Toxicity

Nuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. However, further studies have led to the identification of lipid ligands for some of...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
8.

Gene Expression

Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens

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