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Items: 1 to 20 of 249

1.

Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
2.

Neurodegenerative Diseases

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
3.

Neurodegenerative Diseases

Neurodegenerative diseases manifest as the progressive dysfunction and loss of neurons, which is frequently accompanied by formation of misfolded protein deposits in the brain. Classification of neurodegenerative diseases is based on clinical symptoms, which depend on the anatomical...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

Post-mitotic neurons do not have an active cell cycle. However, deregulation of Cyclin Dependent Kinase-5 (CDK5) activity in these neurons can aberrantly activate various components of cell cycle leading to neuronal death (Chang et al. 2012). Random activation of cell cycle proteins...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

NFG and proNGF binds to p75NTR

When the co-receptor sortilin is present at the cell surface, proNGF preferentially interacts with a p75NTR:sortilin complex. Thus, proNGF, which does not bind TRKA, discriminates between TRKA and p75NTR, in cells that express both receptors. The same is true for proBDNF. Pro-neurotrophin...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)

The human gene SLC6A3 encodes the sodium-dependent dopamine transporter DAT which mediates the Na-dependent re-uptake of dopamine (DA) from the synaptic cleft back into cells, thereby terminating the action of DA (Broer & Gether 2012, Schweikhard & Ziegler 2012). Defects in SLC6A3...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)

The human gene SLC6A3 encodes the sodium-dependent dopamine transporter DAT which mediates the Na-dependent re-uptake of dopamine (DA) from the synaptic cleft back into cells, thereby terminating the action of DA (Broer & Gether 2012, Schweikhard & Ziegler 2012). Defects in SLC6A3...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

Cytokines and Inflammatory Response

Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
9.

Cytokines and Inflammatory Response

Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
10.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Larimichthys crocea
11.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Ictalurus punctatus
12.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Hipposideros armiger
13.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Chrysemys picta bellii
14.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Acinonyx jubatus
15.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Tetraodon nigroviridis
16.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Salmo salar
17.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Saimiri boliviensis boliviensis
18.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Loxodonta africana
19.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Chlorocebus sabaeus
20.

Ferroptosis

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Gekko japonicus

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