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guanosine nucleotides de novo biosynthesis

The first purine nucleotide that is synthesized de novo is : IMP IMP (see :PWY-6123). IMP is converted to : XANTHOSINE-5-PHOSPHATE XMP by the enzyme : IMP-DEHYDROG-CPLX, and the latter is converted to the first guanosine nucleotide, : GMP GMP, by the action of : GMP-SYN-CPLX, an enzyme that can use either glutamine or ammonia as the nitrogen donor. GMP is phosphorylated to : GDP GDP and subsequently to : GTP GTP by the enzymes : GUANYL-KIN-CPLX and : NUCLEOSIDE-DIP-KIN-CPLX, respectively. GDP can be converted to the deoxy form : DGDP dGDP by the enzyme ribonucleoside diphosphate reductase. Once formed, dGDP can be phosphorylated to the DNA building block : DGTP dGTP by the enzyme : NUCLEOSIDE-DIP-KIN-CPLX. In bacterial systems genetic studies indicate that the majority of de novo purine biosynthetic genes are unlinked but may act as a single unit of regulation controlled by the `purR' repressor protein .

from BIOCYC source record: HUMAN_PWY-7228
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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