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aspirin-triggered lipoxin biosynthesis

General Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from : ARACHIDONIC_ACID. These lipid derived mediators play an important role in the cessation of the inflammatory response. : CPD66-53 (ATL) mediates cellular responses and control leukocyte trafficking in vivo by activating the G protein-coupled receptor ALX . Aspirin has well known anti-inflammatory and antipyretic functions. It also has an anti-clotting function through the inhibition of thromboxane synthesis. It is often prescribed long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in high risk patients. Aspirin may also prevent the occurrence of certain types of cancer. About this Pathway This pathway demonstrates the generation of the aspirin triggered 15R series of lipoxins. : CPD66-53 is formed when : HS01115-MONOMER "COX-2" is irreversibly acetylated by aspirin. The acetylated COX-2 is upregulated but loses the ability to generate prostaglandin intermediates. It retains oxygenase activity which results in the production of : CPD66-52 from : ARACHIDONIC_ACID, which leads to the formation of a 15-epimeric form of lipoxin via : HS00336-MONOMER . Statins produce the same effect via S-nitrosylation of COX-2 . The 15-epi lipoxins have similar biological activity to lipoxins.15-epi lipoxin biosynthesis is also triggered by the cytochrome P450 enzymes and this may play a role in the generation of 15-epi lipoxins in the absence of aspirin .

from BIOCYC source record: HUMAN_PWY66-393
Type: pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
782387

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