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adenine and adenosine salvage III

Adenosine nucleotides can be synthesized de novo. In that route : AMP is synthesized via : IMP and : ADENYLOSUCC, which is converted to AMP by the action of : CPLX66-363, see : PWY-7219. Note that the free base : ADENINE or the ribonucleoside : ADENOSINE are not produced via the de novo pathway. Many organisms can also recycle adenosine nucleotides by a combination of degradation and salvage pathways. The degradation pathways are responsible for the conversion of the nucleotides to the nucleoside : ADENOSINE and free base form : ADENINE, and further degradation to compounds that can be catabolized to basic building blocks. The distinction between nucleoside degradation and recycling is not always straight forward. This pathway shares several steps with the pathway : SALVADEHYPOX-PWY. However, this salvage pathway starts with : ADENINE and ends with : IMP, leading to biosynthesis of nucleotides, while the degradation pathway starts with the nucleotide form : AMP and ends with : URATE. A key enzyme in this pathway is : HS02191-MONOMER, which converts : ADENOSINE to : INOSINE. This has been shown to be the main form of adenosine degradation in many fungal species .

from BIOCYC source record: HUMAN_PWY-6609
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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