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proline biosynthesis

General Background : PRO is a non-essential amino acid in that it can be synthesized in the body to meet amino acid requirements. The synthesis of proline in mammals begins with : GLT. This universal pathway is found in all living organisms, though : GLT may arise through different means depending on the organism. In mammals, : GLT is formed in the mitochondrial matrix by NAD(P)+-dependent glutamate dehydrogenases. About this Pathway The first two steps of the pathway are catalyzed by a single enzyme, bifunctional : HS00730-MONOMER which has both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities . The enzyme first phosphorylates L-glutamate and then reduces the product : L-GLUTAMATE-5-P to form : L-GLUTAMATE_GAMMA-SEMIALDEHYDE. The latter compound spontaneously cyclizes to : L-DELTA1-PYRROLINE_5-CARBOXYLATE, which in the last step is converted to :PRO by the universal housekeeping pyrroline-5-carboxylate reductases . : L-GLUTAMATE_GAMMA-SEMIALDEHYDE can also be converted to : L-ORNITHINE by : CPLX-6747 in :ARGININE-SYN4-PWY. The entire pathway occurs within the mitochondria, but the last step may occur in the cytosol depending on which pyrroline-5-carboxylate reductase is used.

from BIOCYC source record: HUMAN_PROSYN-PWY
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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