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ArcAB Two-Component Signal Transduction System, quinone dependent

The ArcAB two-component system mediates E. coli's response to changing respiratory conditions of growth and is a global regulator of gene expression under microaerobic and anaerobic conditions. The system comprises ArcB - a membrane associated sensor kinase and phosphatase, and ArcA - a cytosolic transcription factor. Under anaerobiosis ArcB autophosphorylates and transphosphorylates ArcA via a four step His-Asp-His-Asp phosphorelay. Activated ArcA regulates the expression of numerous operons involved in respiratory and fermentative metabolism. During aerobiosis oxidised forms of quinone electron carriers signal the inhibition of ArcB autophosphorylation and ArcB acts as a specific ArcA-P phosphatase. Reviews:

from BIOCYC source record: ECO_PWY0-1505
Type: pathway
Taxonomic scope
organism-specific biosystem
Escherichia coli

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