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archaeosine biosynthesis

Archaeal tRNA contains |FRAME: CPD-13057| (often referred to as G*), a 7-deazaguanosine modified nucleoside unique to Archaea |CITS: [7683667]|. Archaeosine is found in the majority of archaeal tRNAs specifically at position 15 of the dihydrouridine loop (D-loop) |CITS: [2470031]|, a position not modified in either eukaryotic or bacterial tRNA. The presence of the positively charged formamidine group of archaeosine and its location at the interface of the D-loop/T-stem in the tertiary structure of the tRNA are thought to be important in structural stabilization of the tRNA through electrostatic interactions with the anionic phosphates |CITS: [7683667]|. This is assumed to be a critical role in thermophiles, protecting tRNA from thermal denaturation. The pathway leading to production of the intermediate |FRAME: 7-CYANO-7-DEAZAGUANINE| is common to the archaea and bacteria, and is described in the pathway |FRAME: PWY-6703|. While in bacteria |FRAME: 7-CYANO-7-DEAZAGUANINE| is converted to |FRAME: 7-AMINOMETHYL-7-DEAZAGUANINE| prior to incorporation in tRNA (see |FRAME: PWY-6700|), in archaea |FRAME: 7-CYANO-7-DEAZAGUANINE| is incorporated directly by the archaeal |FRAME: CPLX-8237|, encoded by the |FRAME: G-12503| gene |CITS: [20129918]|. Once incorporated, the enzyme |FRAME: CPLX-8236| catalyzes the direct addition of an ammonia group, generated from glutamine or asparagine hydrolysis, to the nitrile of |FRAME: 7-CYANO-7-DEAZAGUANINE|, a previously unknown amidinotransferase chemistry, generating |FRAME: CPD-13057| within the tRNA |CITS: [20129918]|.

from BIOCYC source record: META_PWY-6711
Type: pathway
Taxonomic scope
conserved biosystem

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