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Alpha6-Beta4 Integrin Signaling Pathway

Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands of the alpha6 beta4 integrin are heterotrimers belonging to the laminin family including Laminin A2, Laminin B1, Laminin C1, Laminin A3, Laminin B3, Laminin C2, Laminin A5, Laminin A1 and Laminin B2 among others. Upon activation, the receptor is phosphorylated and associates with adaptor molecules Shc and Grb2, which then activate the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_1

from WikiPathways source record: WP488
Type: pathway
Taxonomic scope
:
organism-specific biosystem
BSID:
198373

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