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L-arginine degradation II (AST pathway)

This pathway (called the AST pathway for its crucial enzyme, : ARGSUCCTRAN-MONOMER) is the major arginine-degrading pathway found in E. coli. It yields 2 molecules of ammonia and 2 of glutamate and can satisfy E. coli's total nitrogen requirement, but not its total carbon requirement. This pathway does, however, permit other organisms, for example Klebsiella aerogenes, to utilize arginine as a total source of carbon. With the exception of : CPLX0-7947 and : SUCCORNTRANSAM-CPLX "succinylornithine transaminase", enzymes of this pathway from E. coli have not been characterized beyond assaying crude extracts. Succinylornithine transaminase gained special attention and was originally designated as argM because is can substitute for acetylornithine transaminase (encoded by argD) in the biosynthesis of arginine. The substrates of the two enzymes differ only in ornithine's being acetylated in the biosynthetic pathway and succinylated in the degradative pathway. Reviews: Reitzer, L. (2005) "Catabolism of Amino Acids and Related Compounds." EcoSal 3.4.7 ,

from BIOCYC source record: ECO_AST-PWY
Type: pathway
Taxonomic scope
organism-specific biosystem
Escherichia coli

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