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L-serine degradation

Background : SER, is a nonessential amino acid, in that it is synthesized in vivo. It can also be derived from dietary intake, protein degradation and phospholipid degradation. It is not only used in protein synthesis, but also as a precursor for the biosynthesis of glycine in : GLYSYN-PWY, cysteine, tryptophan, and phospholipids. In addition, it directly or indirectly serves as a source of one-carbon units for the biosynthesis of various other compounds . In the mammalian nervous system, : SER is converted to : D-SERINE by : CPLX66-350. D-serine is a co-agonist of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors, a major neurotransmitter receptor family, that require coactivation . About this Pathway The L-serine degradation pathway consists of a single step conversion of : SER to : PYRUVATE and : AMMONIA catalyzed by serine dehydratases . In mammalian liver, this pathway may participate in gluconeogenesis from : SER .

from BIOCYC source record: HUMAN_SERDEG-PWY
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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