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putrescine biosynthesis I

General Backround The polyamines, :PUTRESCINE, :SPERMIDINE,and :SPERMINE, are a group of positively charged organic polycations that are involved in many biological processes, including binding to nucleic acids, stabilizing membranes, and stimulating several enzymes . They play an essential role in the proliferation and development of mammalian cells. Abnormal polyamine metabolism may play a role in carcinogenesis . Depletion of polyamines inhibits the growth of tumor cells. : PUTRESCINE "Putrescine" and : SPERMIDINE are found in all life forms, and : SPERMINE is found mostly in eukaryotes. About This Pathway In this pathway, : PUTRESCINE is generated in a single reaction from : L-ORNITHINE by the : CPLX-6890. : L-ORNITHINE is decarboxylated to : PUTRESCINE for the generation of : PUTRESCINE as a polyamine on its own, or as a precursor for : SPERMIDINE. This is an alternative pathway in mammals to : PWY-40.

from BIOCYC source record: HUMAN_PWY-46
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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