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spermine biosynthesis

General Background The polyamines are a group of positively charged organic polycations that are involved in many biological processes, including binding to nucleic acids, stabilizing membranes, and stimulating several enzymes . The most common are :PUTRESCINE, :SPERMIDINE, and :SPERMINE. While it is clear that polyamines are essential for normal cell growth, we still do not fully understand their specific molecular functions in vivo . :PUTRESCINE "Putrescine" and :SPERMIDINE are found in all life forms, while :SPERMINE is found mostly in eukaryotes. Unlike :SPERMIDINE, :SPERMINE is not essential for viability in eukaryotes. Exogenous :SPERMINE supported growth of :SPERMIDINE-depleted cells only after its degradation into :SPERMIDINE . About this Pathway :SPERMINE "Spermine" is formed by the addition of a propylamine moiety to :SPERMIDINE, catalyzed by an aminopropyltransferase termed : CPLX-6908 . The source of the propylamine group is : S-ADENOSYLMETHIONINAMINE, a decarboxylated : S-ADENOSYLMETHIONINE, which is produced by the action of the pyruvoyl-containing enzyme : CPLX-6906 . The other product of the aminopropyltransferase reaction is :5-METHYLTHIOADENOSINE, which is recycled back to : MET.

from BIOCYC source record: HUMAN_ARGSPECAT-PWY
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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