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adenosine nucleotides degradation

General Background The distinction between nucleoside degradation and salvage is not always straightforward. A general rule is that degradation pathways start with the nucleotide forms and convert them to simpler forms, eventually leading to complete mineralization, while salvage pathways start with either the nucleoside or the free base form, and convert those to the nucleotide forms. Nucleotide recycling is achieved by a combination of both types - a nucleotide is partially degraded via a degradation pathway, but the products are shuttled into a salvage pathway rather then towards complete mineralization. About This Pathway This pathway shares several steps with the pathway : PWY-6609. However, the salvage pathway starts with the free base : ADENINE (which is often transported into the organism) and ends with the nucleotide : IMP, leading to biosynthesis of nucleotides, while this degradation pathway starts with the nucleotide form (: AMP) and ends with : URATE. A key enzyme in this pathway is : HS02191-MONOMER, which converts : ADENOSINE to : INOSINE.

from BIOCYC source record: HUMAN_SALVADEHYPOX-PWY
Type: pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
BSID:
142279

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