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glycine biosynthesis

General Background Mammals can synthesize : GLY via at least three different pathways. The glycine produced can be used in : SER biosynthesis as shown in : GLYSYN-PWY . It can also be used in the biosynthesis of other compounds such as tetrapyrroles and purines, see : PWY-5189 and : PWY-841. Along with serine, glycine is an important donor of one-carbon hydroxymethyl groups via the tetrahydrofolate pathways, as shown in pathways : PWY-2161 and : PWY-2201. The folates act as cofactors and ferry the one-carbon units between reactions. About this Pathway Pyridoxal phosphate dependent alanine-glyxoylate aminotransferases catalyze the conversion of : GLYOX to glycine using : L-ALPHA-ALANINE as the amino donor . Humans possess two isoforms of the enzyme. : CPLX66-332 is the mitochondrial form located primarily in hepatocytes and : CPLX66-331 is targeted to peroxisomes, and found predominantly in the kidney.

from BIOCYC source record: HUMAN_GLYSYN-ALA-PWY
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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