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acetate formation from acetyl-CoA I

General Background |FRAME:ACET "Acetate"| production from |FRAME:ACETYL-COA| can occur via several distinct pathways, which are found in different organisms. Many eubacteria and archaebacteria produce acetate from acetyl CoA via a two-step pathway in which |FRAME:ACETYL-P| occurs as an intermediate (see |FRAME:PWY0-1312|) |CITS: [21941]|. The second reaction, catalyzed by |FRAME:CPLX-101|, results in the generation of ATP from ADP. In many archea |CITS: [8830684]|, some eubacteria (such as |FRAME: TAX-971| |CITS: [Michel90]|), and amitochondriate protists (such as |FRAME: TAX-5759| |CITS: [13076]| and |FRAME: TAX-5741| |CITS: [8557109]|) acetate is produced from acetyl CoA in a single step via the enzyme |FRAME:CPLX-7000|. In this process, the formation of acetate from acetyl CoA concomitantly produces ATP from ADP (see |FRAME:PWY-5535|). A third pathway (|FRAME:PWY-5536|) is found in a diverse group of organisms, which includes the hydrogenosome-containing trichomonads (such as |FRAME: TAX-56690| and |FRAME: TAX-5722| |CITS: [3090435]|), some anaerobic fungi (such as |FRAME: TAX-73818||CITS: [8257282]|), the parasitic helminth |FRAME: TAX-6192| |CITS: [681067][421954][8885873]| and the trypanosomatides |CITS: [9501211][15326192]|. Theser organisms produce acetate from acetyl CoA by |FRAME: MONOMER-13300| (ASCT), an enzyme that transfers the CoA group from |FRAME:ACETYL-COA| to |FRAME:SUC|, producing |FRAME: SUC-COA|. |FRAME: SUC-COA| is restored to |FRAME:SUC| by |FRAME:CPLX-7458|, a TCA cycle enzyme that generates ATP from ADP. About This Pathway |FRAME:ACET "Acetate"| plays multiple roles in the metabolism of |FRAME:TAX-562|. In the absence of other substrates |FRAME: ACET| can serve as a total source of carbon and energy (see |FRAME: PWY0-1313|). During sugar fermentation (under anaerobic conditions), |FRAME: ACET| is produced and excreted into the medium (by a mechanism that is not yet clearly established) as a major fermentation product. |FRAME:ACET "Acetate"| is also produced during aerobic growth in the presence of glucose. Again, |FRAME: ACET| is excreted in significant amounts into the medium, usually to be utilized later, when glucose is depleted. The ack-pta pathway, which is constitutively expressed, can operate in both directions, and participates in both the aerobic utilization of |FRAME: ACET| and in its production (both aerobically and anaerobically). Reviewed in Clark, D.P. and John E. Cronan. EcoSal module 3.4.4 |CITS: [ecosal]|.

from BIOCYC source record: META_PWY0-1312
Type: pathway
Taxonomic scope
conserved biosystem

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