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autoinducer AI-1 biosynthesis

General Background Cell-cell communication in bacteria is accomplished through the exchange of extracellular signalling molecules called autoinducers. This process, termed quorum sensing, allows bacterial populations to coordinate gene expression as a function of cell density. Many processes benefit from community cooperation, including bioluminescence, virulence factor expression, antibiotic production and biofilm development. Autoinducer systems depend on two main components - the autoinducer and its receptor, which also functions as an autoinducer-dependent transcriptional regulator that binds DNA immediately upstream of the genes that are controlled. Autoinducer systems have been implicated in regulation of various systems. For example, |FRAME: G-11135|/luxR of |FRAME: TAX-668| regulate bioluminescence, luxM/luxN of |FRAME: TAX-669| regulate bioluminescence and polyhydroxybutyrate biosynthesis, |FRAME: G-11138|/lasR of |FRAME: TAX-287| regulates virulence factors, |FRAME: G-11136|/rhlR of |FRAME: TAX-287| regulates rhamnolipid synthesis as well as virulence factors, and |FRAME: G-11137|/TraR of |FRAME: TAX-358| regulates plasmid conjugal transfer |CITS: [8905097]|. Several types of autoinducers are known. Gram-negative bacteria typically use |FRAME: Acyl-homoserine-lactones "acyl-homoserine lactones"|, known as type AI-1, as their autoinducers. The first autoinducer to be discovered was |FRAME: CPD-10780|, an AI-1 type compound from |FRAME: TAX-668| |CITS: [7236614]|. Many variants of AI-1 type inducers exist, differing from each other in the composition of the acyl moiety. In some cases, one organism may produce multiple types of acyl homoserine lactone type autoinducers, each produced by a dedicated synthase. A few examples are |FRAME: CPD-10781| from |FRAME: TAX-669|, |FRAME: CPD-10782| from |FRAME: TAX-358|, |FRAME: CPD-10783| and |FRAME: CPD-10784| from |FRAME: TAX-287| and |FRAME: CPD-10780| and |FRAME: CPD-10785| from |FRAME: TAX-668| |CITS: [8905097]|. Another very common family of autoinducers include compounds produced from |FRAME: DIHYDROXYPENTANEDIONE|, which was first described from the marine bacterium |FRAME: TAX-669|, in which it is used to control luciferase expression |CITS:[7984107][9990077]|. AI-2 type compounds are produced by a remarkably wide variety of Gram-negative and Gram-positive bacteria, leading to the proposal that AI-2 is a ?universal? signal that functions in interspecies cell-to-cell communication |CITS: [11544353][18803868]|. About This Pathway This pathway describes a generic reaction for the generation of |FRAME: Acyl-homoserine-lactones "acyl-homoserine lactones"| by the interaction of |FRAME: S-ADENOSYLMETHIONINE| with |FRAME: ACYL-ACP|, releasing |FRAME: 5-METHYLTHIOADENOSINE| and the acyl-binding protein. Sone of the specific reactions are: |FRAME: RXN-10020| |FRAME: RXN-10024| |FRAME: RXN-10023| |FRAME:RXN-10026| |FRAME: RXN-10022| |FRAME: RXN-10025|

from BIOCYC source record: META_PWY-6157
Type: pathway
Taxonomic scope
conserved biosystem

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