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NRAGE signals death through JNK

Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here.

from REACTOME source record: R-HSA-193648
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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