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APC truncation mutants have impaired AXIN binding

Mutations in the APC tumor suppressor gene are common in colorectal and other cancers and cluster in the central mutation cluster region (MCR) of the gene (Miyoshi et al, 1992; Nagase and Nakamura, 1993; Dihlmann et al, 1999; reviewed in Bienz and Clevers, 2000). These mutations generally result in truncated proteins that destabilize the destruction complex and result in elevated WNT pathway activation (reviewed in Polakis, 2000).

from REACTOME source record: R-HSA-5467337
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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