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4-hydroxybenzoate biosynthesis

Mammals synthesize : 4-hydroxybenzoate 4-hydroxybenzoate from : TYR L-tyrosine, as shown in the pathway above. This important pathway has received surprisingly little attention, and has not been well characterized. A pathway for the conversion of : TYR L-tyrosine to : 4-hydroxybenzoate 4-hydroxybenzoate was proposed back in 1960, based on urinary excretion studies on animals administered with various phenolic acids and the incorporation of radiolabeled phenolic acids into ubiquinone by rat liver and yeast . Based on those results, it was suggested that : TYR L-tyrosine is converted to : P-HYDROXY-PHENYLPYRUVATE 4-hydroxyphenylpyruvate, which is then modified to : 4-HYDROXYPHENYLLACTATE 4-hydroxyphenyllactate and : COUMARATE 4-coumarate . These results were confirmed by additional work performed with rat . The later part of the pathway, starting with : COUMARATE 4-coumarate, has not been studied well in animals. In plants it has been shown that : COUMARATE 4-coumarate is converted to : 4-hydroxybenzoate 4-hydroxybenzoate either directly (see : PWY-6431 4-hydroxybenzoate biosynthesis IV) or via CoA derivatives such as : P-COUMAROYL-COA 4-coumaroyl-CoA and : CPD-201 4-hydroxybenzoyl-CoA (see : PWY-6435 4-hydroxybenzoate biosynthesis V).

from BIOCYC source record: HUMAN_PWY-5754
Type: pathway
Taxonomic scope
organism-specific biosystem
Homo sapiens

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