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superpathway of L-aspartate and L-asparagine biosynthesis

Aspartate undergoes a number of reactions that are not in any linear order. One reaction converts the TCA intermediate fumarate to aspartate. Another reaction irreversibly converts aspartate to asparagine. A third reaction facilitates reversible interconversion of aspartate and asparargine. In E. coli aspartate participates in at least two metabolic processes: the regeneration of oxaloacetate as amino-acceptor for enabling growth on glutamate, and the formation of fumarate and succinate during anaerobic growth on glucose. In addition to its role in synthesis of asparagine, aspartate serves as a precursor in synthesis of lysine, methionine and threonine, plus the pyrimidines. Also the intermediate argininosuccinate hydrolyses to give citrulline and aspartate.

from BIOCYC source record: ECO_ASPASN-PWY
Type: pathway
Taxonomic scope
organism-specific biosystem
Escherichia coli

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