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Accession: PRJNA102253 ID: 102253

Homo sapiens (human)

Gene expression profiling of atypical T-ALL

See Genome Information for Homo sapiens
Despite improved therapy, approximately one-fifth of children with acute T-lymphoblastic leukemia (T-ALL) succumb to the disease, suggesting unrecognized biologic heterogeneity that may contribute to drug resistance. We studied leukemic cells, collected at diagnosis, to identify features that could define this high-risk subgroup. A total of 139 patients with T-ALL were treated consecutively from 1992 to 2006 at this institution. Their leukemic cells were examined with multiparameter flow cytometry, single nucleotide polymorphism arrays and other methods of genomic analysis. Survival rates and probabilities of treatment failure were calculated for subgroups considered to have biologically distinct forms of T-ALL. The lymphoblasts of 17 patients (12.2%) had immunophenotypes that clearly differed from those of the remaining patients. Most striking features were the low or absent expression of common T-lineage markers (CD5, CD1a and CD8), and expression of myeloid and stem cell markers, suggesting stem-cell like properties. These atypical blasts also showed a distinct gene expression profile and increased genomic instability overall. Patients with this form of T-ALL had a very low probability of surviving for 10 years after diagnosis: 19% ± 12% (mean ± SE) versus 84% ± 6% for all other patients ( P<0.001). The cumulative incidence of remission failure / hematologic relapse was 72% ± 16% versus 10% ± 3% (P < 0.001). A subset of children with T-ALL have atypical blast cell immunophenotypes that predict a dire outcome with use of standard intensive chemotherapy. Alternative treatment strategies are need for patients with this sybtype of leukemia. Keywords: Analysis of gene expression profiles of typical versus atypical T-ALL Overall design: 55 Diagnostic T-ALL samples were analyzed
AccessionPRJNA102253; GEO: GSE8879
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsCoustan-Smith E et al., "Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.", Lancet Oncol, 2009 Jan 13;10(2):147-56
SubmissionRegistration date: 15-May-2009
Pathology, St Jude Children's Research Hospital
RelevanceMedical
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Resource NameNumber
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PubMed1
PMC1
Other datasets
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Spots1225565
Data volume, Processed Mbytes32
Data volume, Supplementary Mbytes149

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