BioProject

Classical cadherins, a metazoan-specific subfamily of the cadherin superfamily, are homophilic cell-cell adhesion molecules that regulate tissue homeostasis and morphogenesis. More...

Classical cadherins, a metazoan-specific subfamily of the cadherin superfamily, are homophilic cell-cell adhesion molecules that regulate tissue homeostasis and morphogenesis. Although the ectodomains of classical cadherins play conserved roles for homophilic binding interactions, their domain organizations show significant variations among metazoans. To exhaustively search the genome and transcripts of the common house spider Parasteatoda tepidariorum for genes encoding classical cadherins, we obtained sequence data from this species using an Illumina Miseq sequencer. The obtained sequences were analyzed by BLAST to find sequences related to classical cadherin cytoplasmic domains. The sequence data were also used for determining the structures of identified classical cadherin genes, including the exon-intron organizations, and analyzing the transcript expression levels. Less...