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Organizing biological data
XPO1 blockade with KPT-330 promotes apoptosis in Cutaneous T- cell Lymphoma by activating the p53-p21 and p27 pathways
Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in platinum-resistant ovarian cancer by suppressing mitochondrial function and expression of genes related to inflammation and DNA repair.
KPT-330-modulated cold adaptation in various thermogenic organs of prediabetic mice
Gene expression profiling of the carbon pathways and virulence factors of Candida albicans in different carbon sources
NAD+ Metabolism Generates a Metabolic Vulnerability in Endocrine-Resistant Metastatic Breast Tumors
Homo sapiens
Whole-exome sequencing data from patients with concurrent benign thyroid goitre (BTG) and papillary thyroid cancer (PTC).
The mRNA-seq clean result of NOZ cell after KPT-330 treatment for 48h
RNA sequencing of patient-derived AML xenografts treated with Selinexor (KPT-330)
ADAR1 restricts ZBP1–mediated immune response and PANoptosis to promote tumorigenesis
Identification of Nuclear Export Inhibitor-Based Combination Therapies in Preclinical Models of Triple-Negative Breast Cancer
XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor KPT-335.
Targeting DNA damage repair functions of two histone deacetylases, HDAC8 and SIRT6, sensitizes acute myeloid leukemia to NAMPT inhibition
HDAC8i/NAMPTi combination on the transcriptomes of leukemia initiating cells of AML patients
CRM1 inhibitor anti-tumor activity is enhanced with salicylates by S-phase arrest and impaired DNA-damage repair
An organoid screening framework to engineer intestinal epithelial composition
Single-cell epigenomics identifies a premetastatic regulatory program in lung adenocarcinoma [scATAC-seq]
The XPO1 inhibitor KPT-8602 synergizes with dexamethasone for the inhibition of acute lymphoblastic leukemia
Single-cell epigenomics identifies a premetastatic regulatory program in lung adenocarcinoma [sciATAC-seq]
CRISPR-Cas9 screening of KSHV-transformed cells identifies XPO1 as a vulnerable target of cancer cells by inducing p62 SQSTM1-mediated p53 activation in PML bodies
RNASeq analysis of calcification stages (and KPT) in pAVICs
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