BioProject

We provide evidence that a member of the IFN-regulated member of the Schlafen (SLFN) family of proteins, SLFN5, promotes the malignant phenotype in glioblastoma multiforme (GBM). More...

We provide evidence that a member of the IFN-regulated member of the Schlafen (SLFN) family of proteins, SLFN5, promotes the malignant phenotype in glioblastoma multiforme (GBM). Our studies indicate that SLFN5 expression promotes motility and invasiveness of GBM cells, while high levels of SLFN5 expression correlate with shorter overall survival in patients suffering from GBM. To gain further insights into the possible mechanism by which SLFN5 depletion mediates this malignant phenotype, we performed a high-throughput paired-end RNA-sequencing (RNA-seq) on total RNA from SLFN5 depleted cells. Less...