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Genome Information for Homo sapiens
Gene set enhancement analysis (GSEA) revealed that M1 treatment upregulates glycolysis and hypoxia pathway in hallmark gene sets. GSEA revealed that Lonidamine strongly inhibited the IFN-α and IFN-β response pathways after M1 virus infection. GSEA showed that gene sets in unfolded protein response, response to endoplasmic reticulum stress, intrinsic apoptotic signaling pathway were significantly upregulated by Lonidamine plus M1 treatment.
Overall design: HCT 116 tumor cells were treated with control, M1 (MOI=1 pfu/cell), Lonidamine [cp531] (50 μM) or M1 (MOI=1 pfu/cell) plus Lonidamine (50 μM) for 24 hours. Total RNA was extracted from 1×106 cells with TRIzol Reagent (Thermo Fisher Scientific) and was sent for RNA sequencing
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| Accession | PRJNA640682; GEO: GSE152876 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Cai J et al., "Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity.", Cancer Cell Int, 2020 Nov 2;20(1):532 |
| Submission | Registration date: 19-Jun-2020
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| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 12 |
| GEO DataSets | 1 |