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Accession: PRJNA636406 ID: 636406

Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions (bulk RNA) (human)

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This project is a component of the Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions
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1 additional project is a component of the Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions.
66644 additional projects are related by organism.
Comparing the transcriptomic program induced by oleic acid to that of the pro-inflammatory arachidonic acid, we find that Tregs sorted from peripheral blood and adipose of healthy donors transcriptomically resemble the oleic acid in vitro treated Tregs, whereas Tregs obtained from the adipose tissue of relapsing-remitting MS patients more closely resemble an arachidonic acid profile Overall design: Samples were collected from nine healthy subjects for identification of free fatty acid-induced signatures. More...
AccessionPRJNA636406; GEO: GSE151586
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsPompura SL et al., "Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis.", J Clin Invest, 2021 Jan 19;131(2)
SubmissionRegistration date: 1-Jun-2020
UC Berkeley
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments27
Publications
PubMed1
PMC1
Other datasets
BioSample27
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes64
SRA Data Details
ParameterValue
Data volume, Gbases92
Data volume, Mbytes28855

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