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Accession: PRJNA635928 ID: 635928

exhaustion of the regulatory T cell TCR repertoire instigates diabetes in NOD mice

Autoimmune diabetes in NOD mice is instigated by the exhaustion of the activated/memory Treg TCR repertoire, which can be rejuvenated with islet-antigen specific TCRs by low-dose IL-2 stimulation thus preventing diabetes development
AccessionPRJNA635928
Data TypeRaw sequence reads
ScopeMultispecies
Grants
  • "Treg in pathology or disease (TRiPoD)" (Grant ID 322856, European Research Council-Advanced Grant)
SubmissionRegistration date: 29-May-2020
Immunologie,Immunopathologie,Immunotherapie laboratory U959 (INSERM/SU)
RelevanceImmunopathology
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments54
Other datasets
BioSample54
SRA Data Details
ParameterValue
Data volume, Gbases42
Data volume, Mbytes24901

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