BioProject

High T cell infiltration in colorectal cancer (CRC) correlates with a better disease outcome and immunotherapy response. More...

High T cell infiltration in colorectal cancer (CRC) correlates with a better disease outcome and immunotherapy response. This is observed in only a small subset of CRC patients. A better understanding of the factors influencing tumor T cell responses in CRC could inspire novel therapeutic approaches to achieve broader immunotherapy responsiveness. Numerous cell types and factors within the tumor microenvironment (TME) have been described as T cell suppressive within multiple mouse and human cancers. The influence of the TME on T cell infiltration and response in CRC is currently a matter of intense investigation. Here we investigated gene expression of different cell types isolated from mouse colon tumors or control tissue in order to find potential T cell suppressive cues present within these tumors. Overall design: Comparison of samples from sorted neutrophils, monocytes, epithelial and stromal cells from mouse colon tumor or blood of tumor bearing or healthy mice. Less...