See
Genome Information for Homo sapiens
Long non-coding RNAs (lncRNAs) play important roles in the tumorigenesis and progression of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms in nasopharyngeal carcinogenesis (NPC) are largely unknown. In this study, we used the microarray analysis to study the different expression profiles of lncRNAs and mRNAs in human nasopharyngeal carcinoma tissues. We performed genome-wide lncRNAs expression in 3 pairs of NPC and normal nasopharynx tissues and identified 384 dysregulated lncRNAs (fold change ≥2 and P <0.05).
Overall design: Total RNA recovered from 3 pairs of NPC and normal nasopharynx tissues were used to acquire different expression profiles of mRNAs and lncRNAs. In this way, this study provided the basis for identifying novel NPC biomarkers and further studying the roles and functions of differentially expressed lncRNA/mRNA in NPC.
| Accession | PRJNA522988; GEO: GSE126683 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Zheng ZQ et al., "Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3.", Cancer Res, 2019 Sep 15;79(18):4612-4626 |
| Submission | Registration date: 18-Feb-2019
Sun Yat-sen University Cancer Center |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
|---|
| Publications |
| PubMed | 1 |
| Other datasets |
| GEO DataSets | 1 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 353664 |
| Data volume, Processed Mbytes | 8 |
| Data volume, Supplementary Mbytes | 17 |