To explore the genetic landscape of HPV(+) HNSCC compared to HPV(-) HNSCC in a Korean population, with interest in ethnic disparity, we performed whole exome and genome sequencing on untreated Korean HNSCC patients.
More...To explore the genetic landscape of HPV(+) HNSCC compared to HPV(-) HNSCC in a Korean population, with interest in ethnic disparity, we performed whole exome and genome sequencing on untreated Korean HNSCC patients. This analysis revealed a differently patterned stepwise mutagenesis in the pathologically normal but p16(+) crypt epithelium, located in the vicinity of one HPV(+) HNSCC. Considering that the premalignant events leading to the establishment of HPV(+) HNSCC remain unknown, this finding could help further identify biomarkers to determine HPV-driven premalignant changes prior to the establishment of HNSCC, which could assist in early screening.
Less...| Accession | PRJEB18575 |
| Scope | Monoisolate |
| Submission | Registration date: 13-Feb-2019
SEOUL NATIONAL UNIVERSITY COLLEGE OF MEDICINE |
| Locus Tag Prefix | BQ8743 |
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