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Accession: PRJNA522067 ID: 522067

Alterations in GRHL2-OVOL2-ZEB1 Axis and Aberrant Activation of Wnt Signaling Lead to Altered Gene Transcription in Posterior Polymorphous Corneal Dystrophy (human)

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To investigate the molecular basis of posterior polymorphous corneal dystrophy (PPCD) by examining the transcriptome in an affected individuals with an OVOL2 promoter mutation c. More...
AccessionPRJNA522067; GEO: GSE126487
Data TypeTranscriptome or Gene expression
ScopeMultiisolate
OrganismHomo sapiens[Taxonomy ID: 9606]
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
PublicationsChung DD et al., "Alterations in GRHL2-OVOL2-ZEB1 axis and aberrant activation of Wnt signaling lead to altered gene transcription in posterior polymorphous corneal dystrophy.", Exp Eye Res, 2019 Nov;188:107696
SubmissionRegistration date: 13-Feb-2019
Aldave Lab, Ophthalmology, University of California, Los Angeles
RelevanceMedical
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments2
Publications
PubMed1
Other datasets
BioSample2
GEO DataSets1
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes2
SRA Data Details
ParameterValue
Data volume, Gbases8
Data volume, Mbytes3120

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